Officers attended the house in Desmond Road at 9.20am last Wednesday, after receiving information from the public of suspected drug activity inside the address.
A total of 108 cannabis plants with a potential street value of up to £90,700 were found inside the property.
A 24-year-old man was arrested on suspicion of producing a controlled Class B drug and has been released under investigation while enquiries continue.
Inspector Rachel Barrow of the Eastbourne Neighbourhood Policing Team said: “Thanks to information received from the public, we have taken a substantial amount of cannabis off the streets.
“Often cannabis is downplayed in terms of how harmful it can be, but the wider harm associated with it should not be underestimated as it is often a commodity used as part of organised crime and exploitation.
“Our investigation is now ongoing to identify those responsible for producing and bringing harmful drugs into our community.
“We take reports of drug dealing and suspicious activity seriously, and encourage people to continue reporting their concerns to us so we can respond.”